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Cleaved-Caspase-5 p20 (D121) rabbit pAb
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50?L ￥1280.00
100?L ￥1980.00

Overview

产品名称: Cleaved-Caspase-5 p20 (D121) rabbit pAb
反应性: Human;Rat;Mouse;
又名: CASP5; ICH3; Caspase-5; CASP-5; ICE(rel)-III; Protease ICH-3; Protease TY
宿主: Rabbit
稀释比: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
免疫原: The antiserum was produced against synthesized peptide derived from human Caspase 5. AA range:102-151
贮存条件: -20°C/1 year
克隆性: Polyclonal
抗体亚型: IgG
浓度: 1 mg/ml
实测条带: 22kD
基因ID: 838
卵白序列: P51878
细胞定位: neuron projection,neuronal cell body,IPAF inflammasome complex,NLRP1 inflammasome complex,NLRP3 inflammasome complex,AIM2 inflammasome complex,
研究配景: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010],
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