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Overview 文献(21)
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cell death & differentiation
Epithelial MST1 deficiency promotes pyroptosis and aggravates inflammatory bowel disease via the YAP/p73 signaling pathway
日期：2025-09-17
IF：15.4
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Biomaterials
Dual-targeting nuclear and mitochondrial DNA damage drives immunogenic activation via PANoptosis for synergistic magneto-thermodynamic-chemotherapy
日期：2025-12-15
IF：12.9
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Materials Today Bio
Macrophage membrane-biomimetic nanovehicles delivering amygdalin halt pyroptosis propagation and alleviate endometriosis-associated neuropathic pain
日期：2026-04-20
IF：10.2
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Biomaterials Research
The Strontium Ion Reprograms Monocyte Subsets via TRPM2 Channel Regulation to Enhance Osseointegration
日期：2025-11-02
IF：9.6
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ACS Applied Materials & Interfaces
Inhibition of Transmural Inflammation in Crohn’s Disease by Orally Administered Tumor Necrosis Factor-Alpha Deoxyribozymes-Loaded Pyroptosis Nanoinhibitors
日期：2024-07-25
IF：8.3
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International Journal of Biological Macromolecules
Gut microbiota-derived 5-hydroxyindoleacetic acid from pumpkin polysaccharides supplementation alleviates colitis via MAPKs-PPARγ/NF-κB inhibition
日期：2024-04-30
IF：7.7
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Food Science and Human Wellness
Oral supplementation of TMAO Promotes Vascular Calcification in db/db Mice by Regulating the SIRT1/NF-κB p65/NLRP3 Signaling Axis and the Intestinal Microbiota
日期：1970-01-01
IF：7.4
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Experimental Neurology
Exosomal miR-23b-3p from bone mesenchymal stem cells alleviates experimental autoimmune encephalomyelitis by inhibiting microglial pyroptosis
日期：2023-05-01
IF：5.62
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Biomolecules
Dehydroandrographolide Alleviates Oxidative Stress, Inflammatory Response, and Pyroptosis in DSS-Induced Colitis Mice by Modulating Nrf2 Signaling Pathway
日期：2025-11-04
IF：4.8
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CNS Neuroscience & Therapeutics
The Circadian Clock Gene Bmal1 Regulates Microglial Pyroptosis After Spinal Cord Injury via NF-κB/MMP9
日期：2024-12-08
IF：4.8
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Experimental Neurology
KIF23 inhibition protects against perioperative neurocognitive disorders by hindering ROS/caspase-3/GSDME-mediated pyroptosis
日期：2025-07-06
IF：4.2
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International Immunopharmacology
Extracellular vesicles containing miR-181a-5p as a novel therapy for experimental autoimmune encephalomyelitis-induced demyelination
日期：2024-06-30
IF：4
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International Journal of Hyperthermia
Microwave ablation combined with anti-PD-1 therapy enhances systemic antitumor immunity in a multitumor murine model of Hepa1-6
日期：2022-02-06
IF：3.914
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The American Journal of Pathology
E3 Ubiquitin Ligase TRIM7 Alleviates Lipopolysaccharide-Induced Acute Lung Injury via Inhibiting NLRP3 Inflammasome Activation
日期：2025-01-24
IF：3.6
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Frontiers in Bioscience-Landmark
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy
日期：2025-03-05
IF：3.1
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JOURNAL OF PHARMACY AND PHARMACOLOGY
Mesenchymal stem cell-derived exosomal microRNA-367-3p mitigates lower limb ischemia/reperfusion injury in mouse skeletal muscle via EZH2 targeting
日期：2024-08-13
IF：2.8
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Evidence-based Complementary and Alternative Medicine
Sulforaphane Ameliorates Limb Ischemia/Reperfusion-Induced Muscular Injury in Mice by Inhibiting Pyroptosis and Autophagy via the Nrf2-ARE Pathway
日期：2022-05-11
IF：2.629
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PLoS One
GBP2 promotes podocyte pyroptosis and contributes to the pathogenesis of pediatric lupus nephritis
日期：2026-03-19
IF：2.6
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PARASITE LMMUNOLOGY
Pyroptosis Tuning in Intestinal Cryptosporidiosis via the Natural Histone Deacetylase Inhibitor Romidepsin
日期：2024-03-18
IF：2.2
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BMC Cardiovascular Disorders
Bone marrow mesenchymal stem cellsderived exosomes stabilize atherosclerosis through inhibiting pyroptosis
日期：2023-08-16
IF：2.1
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International Journal of Ophthalmology
Protective effects of CY-09 and astaxanthin on NaIO3-induced photoreceptor inflammation via the NLRP3/autophagy pathway
日期：2024-07-18
IF：1.9
标准曲线
| Concentration (pg/mL) | OD | Corrected OD |
|---|---|---|
| 8000.00 | 1.941 | 1.853 |
| 4000.00 | 1.484 | 1.396 |
| 2000.00 | 1.036 | 0.948 |
| 1000.00 | 0.625 | 0.537 |
| 500.00 | 0.373 | 0.285 |
| 250.00 | 0.300 | 0.212 |
| 125.00 | 0.216 | 0.128 |
| 0.00 | 0.088 | 0.000 |
细密度
板内细密度（测定内的细密度）：CV%<8%
三个已知浓度的样品划分在1个酶标板上测试20次，，，，，以评估剖析板内细密度。。。。。
板间细密度（测定板间间细密度）：CV%<10%
三个已知浓度的样品划分在3个差别的酶标板上测试40次，，，，，以评估剖析板间的细密度。。。。。
接纳率
划分往差别样本中添加已知浓度的小鼠 IL18，，，，，
做接纳率实验，，，，，得出接纳率规模清静均接纳率
| 样本类型 | 接纳率规模 | 平均接纳率 |
|---|---|---|
| 血清(n=5) | 91-99% | 95% |
| EDTA 血浆(n=5) | 82-95% | 88% |
| Heparin 血浆(n=5) | 83-98% | 91% |
线性
将添加有小鼠 IL18的样天职别稀释2倍，，，，，4倍，，，，，8倍，，，，，16倍做接纳实验，，，，，得出接纳率规模
| 样本类型 | 1:2 | 1:4 | 1:8 | 1:16 |
|---|---|---|---|---|
| 血清(n=5) | 86-97% | 90-98% | 80-93% | 92-105% |
| EDTA 血浆(n=5) | 87-98% | 85-92% | 79-96% | 89-100% |
| Heparin 血浆(n=5) | 79-91% | 89-103% | 82-95% | 86-99% |
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