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Overview 文献(47)
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Journal of Biomedical Science
Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency
日期：2021-06-15
IF：12.771
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Nano Research
Oral pyroptosis nanoinhibitor for the treatment of inflammatory bowel disease
日期：2023-07-31
IF：9.9
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Phytomedicine Plus
Gentiopicroside attenuates lupus arthritis by targeting galectin-mediated macrophage activation
日期：2026-02-03
IF：8.3
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Environmental Research
Evaluation of genotoxicity, oxidative stress and immune parameters of auto-paint workers
日期：2023-04-28
IF：8.3
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Biomedicine & Pharmacotherapy
JNK downregulation improves olanzapine-induced insulin resistance by suppressing IRS1Ser307 phosphorylation and reducing inflammation
日期：2021-08-17
IF：6.529
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Journal of Translational Medicine
Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism
日期：2024-08-07
IF：6.1
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Journal of Leukocyte Biology
PKM2 Promotes Pro-Inflammatory Macrophage Activation in Ankylosing Spondylitis
日期：2023-05-16
IF：6.011
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Frontiers in Immunology
Laptm4a mediates renal ischemia-reperfusion injury by regulating the UNC5B-AKT/mTOR signaling pathway
日期：2026-04-14
IF：5.9
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Cell Proliferation
Targeting ROCK1/YAP1 Axis Ameliorates Inflammation-Induced Prostatic Hyperplasia via Stabilising SIRT1-Dependent Mitochondrial Dynamics
日期：2025-06-09
IF：5.6
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Journal of Leukocyte Biology
PKM2 promotes proinflammatory macrophage activation in ankylosing spondylitis
日期：2023-05-16
IF：5.5
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Life Sciences
Icariin protects neurons from endoplasmic reticulum stress-induced apoptosis after OGD/R injury via suppressing IRE1α-XBP1 signaling pathway
日期：2020-05-25
IF：5.037
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Drug Development Research
Knockdown of IGF2BP3 inhibits the tumorigenesis of gallbladder cancer and modifies tumor microenvironment
日期：2022-10-02
IF：5.004
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Frontiers in Oncology
Downregulation of hsa_circ_0001836 Induces Pyroptosis Cell Death in Glioma Cells via Epigenetically Upregulating NLRP1
日期：2021-03-31
IF：4.848
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Journal of Ethnopharmacology
Integration of network pharmacology, bioinformatics and experimental verification strategy to discover the pharmacological mechanisms of mogroside acts against pharyngitis
日期：2025-02-28
IF：4.8
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IUBMB Life
Addressing the impact of high glucose microenvironment on the immunosuppressive characteristics of human mesenchymal stem cells
日期：2023-11-28
IF：4.6
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Probiotics and Antimicrobial Proteins
The Anti-inflammatory, Antioxidant Effects and Protective Barrier Function of Cell-Free Supernatant of Potential Probiotic Staphylococcus epidermidis CCSM0322 in HaCaT Cell Induced by UVB
日期：2025-12-15
IF：4.4
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Clinical Epigenetics
Clinical significance and prognostic value of SIRT1 genetic variants in sepsis: a multicenter hospital-based case–control study
日期：2025-07-21
IF：4.4
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Frontiers in Pharmacology
Xanthohumol ameliorates diabetic kidney disease through suppression of renal fibrosis by regulating SNHG10/miR-378b
日期：2025-05-27
IF：4.4
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Human Cell
Exosomal hsa_circ_0017252 attenuates the development of gastric cancer via inhibiting macrophage M2 polarization
日期：2022-07-07
IF：4.374
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Gut Pathogens
A triad of gut dysbiosis, dysregulated immunity, and ‘leaky’ gut characterize HCMV associated neonatal cholestasis
日期：2024-11-14
IF：4.3
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Journal of Inflammation Research
Alpha-Taxilin: A Potential Diagnosis and Therapeutics Target in Rheumatoid Arthritis Which Interacts with Key Glycolytic Enzymes Associated with Metabolic Shifts in Fibroblast-Like Synoviocytes
日期：2024-11-29
IF：4.2
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Cancer Medicine
Anti-tumorigenic effects of naive and TLR4-primed adipose-derived mesenchymal stem cells on pancreatic ductal adenocarcinoma cells
日期：2024-02-01
IF：4
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Journal of Intensive Care
Low levels of CD72 and CD100 expression on circulating lymphocytes in immunosuppressive phase of sepsis is associated with mortality in septic patients
日期：2020-09-03
IF：3.953
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scientific reports
Potential predictors of COVID-19 disease infection and severity in Egypt
日期：2026-01-29
IF：3.9
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BIOMEDICINES
Necroptotic and Apoptotic Pathways in Sepsis: A Comparative Analysis of Pediatric and Adult ICU Patients
日期：2025-07-14
IF：3.9
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Molecular and Cellular Biochemistry
Senescent cell clearance suppresses post-radiotherapy glioblastoma recurrence via the IL-6/JAK2/STAT3 pathway
日期：2025-11-23
IF：3.7
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Cardiovascular Toxicology
Thiolutin Alleviates Cardiotoxic Effects of Doxorubicin by Suppressing NLRP3 Inflammasome in the Mouse Model
日期：2024-12-11
IF：3.4
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Bioengineered
Knockdown of lncRNA PCAT6 suppresses the growth of non-small cell lung cancer cells by inhibiting macrophages M2 polarization via miR-326/KLF1 axis
日期：2022-05-24
IF：3.269
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Ruminococcaceae promotes the NLRP3/ASC/Caspase-1 axis–mediated pyroptotic signaling in papillary thyroid carcinoma by upregulating RBM15 to increase the N6-methyladenosine methylation modulation of NLRP3
日期：2026-02-02
IF：3.1
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ORAL DISEASES
Effects of D3K2 With Periodontal Therapy in Diabetes Mellitus and Stage I-II Periodontitis Patients
日期：2024-10-06
IF：2.9
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EXPERIMENTAL BIOLOGY AND MEDICINE
The correlation between pro- and anti-inflammatory cytokines and anti-spike IgG antibody responses induced by the SARS-CoV-2 coronavirus vaccine
日期：2026-01-14
IF：2.8
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MOLECULAR BIOLOGY REPORTS
Cytokine profiles and metabolic dysregulation in endometriosis: insights into diagnostic and therapeutic targets
日期：2025-06-26
IF：2.8
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Medical Oncology
Dual facets of MSC-derived small EVs: regulatory insights into antitumor mechanisms in pancreatic ductal adenocarcinoma
日期：2025-04-10
IF：2.8
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Immunity, Inflammation and Disease
Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF-κB Pathway
日期：2026-03-07
IF：2.7
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ASIAN JOURNAL OF ANDROLOGY
NLRP3 activation by lipopolysaccharide (LPS) mediates the pyroptosis of human spermatogonial stem cells via GBP4 regulation
日期：2026-01-16
IF：2.7
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EXPERIMENTAL BIOLOGY AND MEDICINE
The correlation between proand anti-inflammatory cytokines and anti-spike IgG antibody responses induced by the SARS-CoV-2 coronavirus vaccine
日期：2025-12-14
IF：2.7
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Immunity, Inflammation and Disease
PLSCR1 Regulates the Physiology of Fibroblast-Like Synoviocytes via Modulating the STAT1 Signaling Pathway
日期：2025-10-17
IF：2.7
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Immunity, Inflammation and Disease
Amphiregulin Promotes Proliferation and Migration of the Damaged Endothelial Cells in Kawasaki Disease Cell Models
日期：2025-06-26
IF：2.7
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Reproductive Sciences
The Impact of Inflammatory Cytokines on Recurrent Pregnancy Loss: A Preliminary Investigation
日期：2025-01-22
IF：2.6
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International Journal of Immunogenetics
HDAC3-mediated lncRNA ZFAS1 inhibited IL-13-induced secretion of proinflammatory cytokines in nasal epithelial cells by regulating the miR-7-5p/SIRT1 pathway
日期：2023-09-12
IF：2.2
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Open Medicine
ANO6 (TMEM16F) inhibits gastrointestinal stromal tumor growth and induces ferroptosis
日期：2024-05-15
IF：2.1
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CYTOTECHNOLOGY
Mechanism underlying the role of the circRNA OMA1/miR-654-3p/RAF1 axis in children with inflammatory bowel disease
日期：2025-01-25
IF：2
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Cell Biochemistry and Biophysics
The Impact of Liraglutide, a GLP-1 Receptor Agonist, on High Glucose-Induced Inflammation, Apoptosis, Oxidative Stress, and NLRP3 Signaling
日期：2025-04-11
IF：1.8
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Open Medicine
Signi?cant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease
日期：2024-11-18
IF：1.7
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Artery Research
Correlation of NLRP3 and Downstream Inflammatory Factors in Patients with Different Types of Coronary Heart Disease
日期：2025-12-16
IF：1.6
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JOURNAL OF ASTHMA
STOML2 Knockdown Inhibits Inflammation and Airway Remodeling of PDGF-BB-Induced Airway Smooth-Muscle Cells by the MAPK Pathway
日期：2025-08-06
IF：1.3
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Biomedical and Biotechnology Research Journal (BBRJ)
Impact of Proinflammatory Cytokines: (Interleukin 6, Interleukin 1α, and Interleukin 1β) on Biochemical Parameters in Severe Acute Respiratory Syndrome Coronavirus 2 Patients in Iraq
日期：2022-06-17
IF：1.1
标准曲线
| Concentration (pg/mL) | OD | Corrected OD |
|---|---|---|
| 1000.00 | 2.207 | 2.125 |
| 500.00 | 1.613 | 1.531 |
| 250.00 | 1.115 | 1.033 |
| 125.00 | 0.757 | 0.675 |
| 62.50 | 0.421 | 0.339 |
| 31.25 | 0.297 | 0.215 |
| 15.63 | 0.195 | 0.113 |
| 0.00 | 0.082 | 0.000 |
细密度
板内细密度（测定内的细密度）：CV%<8%
三个已知浓度的样品划分在1个酶标板上测试20次，，，，以评估剖析板内细密度。。。
板间细密度（测定板间间细密度）：CV%<10%
三个已知浓度的样品划分在3个差别的酶标板上测试40次，，，，以评估剖析板间的细密度。。。
接纳率
划分往差别样本中添加已知浓度的人 IL1b，，，，
做接纳率实验，，，，得出接纳率规模清静均接纳率
| 样本类型 | 接纳率规模 | 平均接纳率 |
|---|---|---|
| 血清(n=5) | 92-105% | 98% |
| EDTA 血浆(n=5) | 83-95% | 89% |
| Heparin 血浆(n=5) | 79-93% | 86% |
线性
将添加有人 IL1b的样天职别稀释2倍，，，，4倍，，，，8倍，，，，16倍做接纳实验，，，，得出接纳率规模
| 样本类型 | 1:2 | 1:4 | 1:8 | 1:16 |
|---|---|---|---|---|
| 血清(n=5) | 87-93% | 91-103% | 82-99% | 99-104% |
| EDTA 血浆(n=5) | 84-99% | 81-95% | 98-107% | 96-101% |
| Heparin 血浆(n=5) | 86-105% | 84-98% | 95-102% | 88-106% |
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