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Overview 文献(100)
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Bioactive Materials
Minimally invasive bioprinting for in situ liver regeneration
日期：2023-03-11
IF：18.9
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Journal of Neuroinflammation
Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis
日期：2021-11-02
IF：9.587
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Brain Behavior and Immunity
Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation
日期：2022-02-15
IF：8.8
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Phytomedicine
Lianweng formula restores intestinal barrier function in ulcerative colitis through the β-arrestin 1/NF-κB signaling axis
日期：2025-08-10
IF：8.3
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Biomaterials Research
Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis
日期：2023-01-17
IF：8.1
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Journal of Orthopaedic Translation
Synovial Advanced Glycosylation End Products Aggravate Periprosthetic Infection in Diabetes by Upregulating Staphylococcus Aureus RNAIII
日期：2024-04-08
IF：7.8
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CLINICAL SCIENCE
Evaluating the role of 2-hydroxyestradiol in modulating TNF-α signaling and its implications in rheumatoid arthritis
日期：2025-09-22
IF：7.7
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BIOMEDICINE & PHARMACOTHERAPY
Metformin ameliorates olanzapine-induced insulin resistance via suppressing macrophage infiltration and inflammatory responses in rats
日期：2020-11-17
IF：7.419
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British Journal of Pharmacology
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression
日期：2024-05-13
IF：7.3
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Cellular and Molecular Gastroenterology and Hepatology
Activation of AMPK by metformin inhibits dedifferentiation of PDGF-BB-induced vascular smooth muscle cells to improve arterial remodeling in cirrhotic portal hypertension
日期：2025-02-28
IF：7.1
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Bioengineered
Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction
日期：2021-11-25
IF：6.832
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Antioxidants
Protective Effects of Curcumin and Sulforaphane Against Ionising Radiation–Induced Oxidative Stress and Inflammatory Responses in Rat Lung Tissue
日期：2026-03-18
IF：6.6
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Frontiers in Nutrition
A Dietary Supplement Containing Micronutrients, Phosphatidylserine, and Docosahexaenoic Acid Counteracts Cognitive Impairment in D-Galactose-Induced Aged Rats
日期：2022-07-05
IF：6.59
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Veterinary Quarterl
Modulating effects of heat-killed and live Limosilactobacillus reuteri PSC102 on the immune response and gut microbiota of cyclophosphamide-treated rats
日期：2024-04-29
IF：6.4
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Frontiers in Pharmacology
Vagus Nerve Stimulation Attenuates Acute Skeletal Muscle Injury Induced by Hepatic Ischemia/Reperfusion Injury in Rats
日期：2022-01-03
IF：5.988
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Frontiers in Pharmacology
Alpha-Lipoic Acid Protects Co-Exposure to Lead and Zinc Oxide Nanoparticles Induced Neuro, Immuno and Male Reproductive Toxicity in Rats
日期：2021-07-08
IF：5.81
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Biochemical Pharmacology
Febuxostat alleviates Arsenic Trioxide-Induced renal injury in Rats: Insights on the crosstalk between NLRP3/TLR4, Sirt-1/NF-κB/TGF-β signaling Pathways, and miR-23b-3p, miR-181a-5b expression
日期：2023-09-06
IF：5.8
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Environmental Science and Pollution Research
Combined β?sitosterol and trimetazidine mitigate potassium dichromate?induced cardiotoxicity in rats through the interplay between NF?κB/AMPK/mTOR/TLR4 and HO?1/NADPH signaling pathways
日期：2023-04-10
IF：5.8
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Aging
LncRNA AC136007.2 alleviates cerebral ischemic-reperfusion injury by suppressing autophagy
日期：2021-08-13
IF：5.682
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Frontiers in Molecular Neuroscience
A Noradrenergic Lesion Attenuates Surgery-Induced Cognitive Impairment in Rats by Suppressing Neuroinflammation
日期：2021-11-30
IF：5.639
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International Immunopharmacology
Unlocking the miRNA-34a-5p/TGF-β and HMGB1/PI3K/Akt/mTOR crosstalk participate in the enhanced cardiac protection of liraglutide against isoproterenol-induced acute myocardial injury rat model
日期：2023-12-10
IF：5.6
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International Immunopharmacology
Dapagliflozin alleviates arsenic trioxide-induced hepatic injury in rats via modulating PI3K/AkT/mTOR, STAT3/SOCS3/p53/MDM2 signaling pathways and miRNA-21, miRNA-122 expression
日期：2023-11-27
IF：5.6
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International Immunopharmacology
Restoring glomerular filtration rate by sulforaphane modulates ERK1/2/JNK/p38MAPK, IRF3/iNOS, Nrf2/HO-1 signaling pathways against folic acid-induced acute renal injury in rats
日期：2023-08-06
IF：5.6
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Nanomedicine
Age-dependent assessment of selenium nanoparticles: biodistribution and toxicity study in young and adult rats
日期：2023-10-31
IF：5.5
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Journal of Ethnopharmacology
The Material Basis and Underlying Mechanism of Folium Artemisiae Argyi in Warming Meridians and Alleviating Pain in a Rat Model of Cold-Dampness Stagnation Primary Dysmenorrhea
日期：2026-01-16
IF：5.4
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Pakistan Veterinary Journal
Combretol Mitigates Paclitaxel-Instigated Hepatotoxicity Via Counteracting Oxidative Stress, Apoptosis and Inflammation
日期：2025-10-03
IF：5.4
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Journal of Ethnopharmacology
Ameliorative effect of AYUSH formulation against scopolamine induced learning and memory impairment in rat via attenuation of oxidative stress, neuroinflammation, acetylcholinesterase inhibition and Aβ plaques
日期：2026-05-12
IF：5.4
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Journal of Ethnopharmacology
Integrating UPLC-Q-Exactive Orbitrap/MS, network pharmacology and experimental validation to reveal the potential mechanism of Tibetan medicine Rhodiola granules in improving myocardial ischemia-reperfusion injury
日期：2023-05-20
IF：5.195
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Molecular Neurobiology
Diosmetin Ameliorates HFD-induced Cognitive Impairments via Inhibiting Metabolic Disorders, Mitochondrial Dysfunction and Neuroinflammation in Male SD Rats
日期：2024-03-09
IF：5.1
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Drug Design Development and Therapy
Sacubitril/Valsartan Fails to Ameliorate Cisplatin-Induced Cognitive Impairment
日期：2026-05-20
IF：5.1
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Drug Design Development and Therapy
Sacubitril/Valsartan Fails to Ameliorate Cisplatin-Induced Cognitive Impairment
日期：2026-05-20
IF：5.1
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LIFE SCIENCES
Naringin ameliorates type 2 diabetes mellitus-induced steatohepatitis by inhibiting RAGE/NF-κB mediated mitochondrial apoptosis
日期：2020-07-24
IF：5.037
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Scientific Reports
Vagus nerve stimulation attenuates acute kidney injury induced by hepatic ischemia/reperfusion injury in rats
日期：2022-12-15
IF：4.996
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Scientific Reports
Vagus Nerve Stimulation Attenuates Acute Kidney Injury Induced by Hepatic Ischemia/Reperfusion Injury by Suppressing Inflammation, Oxidative Stress, and Apoptosis in Rats
日期：2022-08-17
IF：4.996
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Molecules
Cornus mas L. Extract Targets the Specific Molecules of the Th17/Treg Developmental Pathway in TNBS-Induced Experimental Colitis in Rats
日期：2023-03-29
IF：4.927
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Frontiers in Bioengineering and Biotechnology
The role of PRP in the healing of disc degeneration and the effect of local anesthetics on PRP
日期：2025-06-18
IF：4.8
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International Immunopharmacology
Combined sulforaphane and β-sitosterol mitigate olanzapine-induced metabolic disorders in rats: Insights on FOXO, PI3K/AKT, JAK/STAT3, and MAPK signaling pathways
日期：2024-10-25
IF：4.8
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International Immunopharmacology
Combined diosmin and bisoprolol attenuate cobalt chloride-induced cardiotoxicity and endothelial dysfunction through modulating miR-143-3P/MAPK/MCP-1, ERK5/CXCR4, Orai-1/STIM-1 signaling pathways
日期：2024-10-25
IF：4.8
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Pharmaceuticals
Revealing the Pharmacological Mechanism of Tibetan Medicine Wugeng San in Treating Rheumatoid Arthritis Through an Integrated Strategy of Chemical Composition Analysis, Network Pharmacology, Machine Learning, and In Vivo Experiments
日期：2026-04-30
IF：4.8
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BIOMEDICINE & PHARMACOTHERAPY
Vagus nerve stimulation protects against acute liver injury induced by renal ischemia reperfusion via antioxidant stress and anti-inflammation
日期：2019-06-06
IF：4.696
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Microorganisms
Timing-Dependent Effects of Prebiotic–Probiotic Supplementation on High-Fat-Diet-Induced Testicular Dysfunction and Gut Microbiota Alterations in Rats
日期：2026-07-17
IF：4.7
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Journal of Inflammation Research
Oral Lycopene Administration Attenuates Inflammation and Oxidative Stress by Regulating Plasma Lipids in Rats with Lipopolysaccharide-Induced Epididymitis
日期：2022-11-29
IF：4.631
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Frontiers in Pharmacology
Sacubitril/valsartan fails to prevent doxorubicin-induced cognitive impairment and hippocampal oxidative, inflammatory, and apoptotic alterations in rats
日期：2026-01-06
IF：4.6
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MOLECULAR NUTRITION & FOOD RESEARCH
Excess Fructose Intake Activates Hyperinsulinemia and Mitogenic MAPK Pathways in Association With Cellular Stress, Inflammation, and Apoptosis in the Pancreas of Rats
日期：2025-03-28
IF：4.5
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ARTHRITIS RESEARCH & THERAPY
Integrative metabolomic-proteomic analysis uncovers a new therapeutic approach in targeting rheumatoid arthritis
日期：2024-12-23
IF：4.4
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Frontiers in Pharmacology
Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation
日期：2024-12-12
IF：4.4
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ARTHRITIS RESEARCH & THERAPY
Integrative Metabolomic-Proteomic Analysis Uncovers a New Therapeutic Approach in Targeting Rheumatoid Arthritis
日期：2024-10-07
IF：4.4
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Scientific Reports
Human β-defensin-3 reduces excessive autophagy in intestinal epithelial cells and in experimental necrotizing enterocolitis
日期：2019-12-13
IF：4.379
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ACS Omega
Long-Term In Situ Treatment of Arthritis with Injectable Biocompatible Organogel Activation
日期：2025-07-31
IF：4.3
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Pharmaceuticals
Therapeutic Potential of Ambroxol in Osteoarthritis: A Drug Repurposing Study
日期：2026-04-27
IF：4.3
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Experimental Gerontology
Hesperidin inhibits NOX4 mediated oxidative stress and inflammation by upregulating SIRT1 in experimental diabetic neuropathy
日期：2022-12-19
IF：4.253
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Journal of Inflammation Research
Is Lipopolysaccharide-Induced Lipid Metabolism Disorder in Testis of Rats a Consequence of Plasma Lipid Changes?
日期：2024-02-07
IF：4.2
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Biological Trace Element Research
N-Acetylcysteine May Regulate Altered Meteorin-Like Levels in Testicular Tissue due to Aluminum Exposure
日期：2023-04-04
IF：4.081
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Brain Research Bulletin
Nuclear receptor TLX may be through regulating the SIRT1/NF-κB pathway to ameliorate cognitive impairment in chronic cerebral hypoperfusion
日期：2020-11-10
IF：4.077
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Food and Chemical Toxicology
MiADMSA abrogates chronic copper-induced hepatic and immunological changes in Sprague Dawley rats
日期：2020-08-29
IF：4.06
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Heliyon
Nicotine plays a protective role in rats with induced viral pneumonia with polyinosinic-polycytidylic acid through α7nAChR
日期：2023-10-26
IF：4
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scientific reports
Nicorandil attenuates thioacetamide induced liver fibrosis via AMPK, SIRT1 and HIF1α mediated cellular energy homeostasis
日期：2025-11-10
IF：3.9
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BIOSCIENCE REPORTS
Clo-miR-14: a medicinally valued spice-derived miRNA with therapeutic implications in rheumatoid arthritis
日期：2024-09-10
IF：3.8
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Brain Research Bulletin
The environmental enrichment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive decline by inducing autophagy-mediated inflammation inhibition
日期：2022-07-08
IF：3.715
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Journal of Psychiatric Research
rTMS ameliorates CUMS-induced anxiety-depression-like behaviour and cognitive dysfunction in rats by modulating the COX-2/PGE2 signalling pathway
日期：2025-05-08
IF：3.7
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JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
Reno-protective effect of nicorandil and pentoxifylline against potassium dichromate-induced acute renal injury via modulation p38MAPK/Nrf2/HO-1 and Notch1/TLR4/NF-κB signaling pathways
日期：2024-09-05
IF：3.6
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Non-Coding RNA
Functional Significance of miR-4693-5p in Targeting HIF1α and Its Link to Rheumatoid Arthritis Pathogenesis
日期：2024-04-16
IF：3.6
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Apigenin protects melanocytes and improve tyrosinase activity in a hydroquinone induced vitiligo mouse model targeting P38 MAP kinase signaling: histopathology and immunohistochemistry analysis
日期：2023-12-29
IF：3.6
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Pharmaceutical Biology
Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia
日期：2021-10-06
IF：3.503
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METABOLIC BRAIN DISEASE
Adropin ameliorates behavioral seizures and the relevant neuroinflammation, oxidative stress, and neural damage in a rat model of pentylenetetrazole-induced seizure potentially by reducing the activation of NF-κB/IkB-α signaling pathway
日期：2025-06-13
IF：3.5
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Heliyon
Silencing miR-155–5p expression improves intestinal damage through inhibiting inflammation and ferroptosis in necrotizing enterocolitis
日期：2024-09-15
IF：3.4
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Journal of Trace Elements in Medicine and Biology
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via modulating SIRT1/FOXO3a and HO-1/ferritin pathways: A biochemical, histopathological and computational approaches
日期：2026-04-30
IF：3.3
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Biochemical and Molecular Toxicology
AGK2, a SIRT2 inhibitor, ameliorates D-galactose-induced liver fibrosis by inhibiting fibrogenic factors
日期：2024-10-13
IF：3.2
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The Journal of Infectious Diseases
The Efficacy and Safety of an Intra-articular Dual-Acting Antibacterial Agent (TNP-2092) for Implant Infection–Associated Methicillin-Resistant Staphylococcus aureus
日期：2023-12-26
IF：3.2
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Environmental Toxicology
Syringic acid alleviates valproic acid induced autism via activation of p38 mitogen-activated protein kinase: Possible molecular approach
日期：2023-06-26
IF：3.2
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
The hepatoprotective role of piperazine ferulate against cisplatin-induced hepatotoxicity in rats: insights into the Keap1/Nrf-2/HO-1 signaling and inflammatory pathways
日期：2025-11-14
IF：3.1
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
Exploring the drug repurposing potential of lisinopril against TNBS-induced colitis in Wistar rats
日期：2025-05-06
IF：3.1
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Naunyn-Schmiedeberg's Archives of Pharmacology
Cilostazol alleviates imatinib-induced myocardial injury in rats by modulating the TGF-β1/MAPK, SHC/Grb2/SOS signaling pathways and upregulating miRNA-195-5P
日期：2025-03-18
IF：3.1
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Naunyn-Schmiedeberg's Archives of Pharmacology
Piperazine ferulate impact on diabetes-induced testicular dysfunction: unveiling genetic insights, MAPK/ERK/JNK pathways, and TGF-β signaling
日期：2024-12-13
IF：3.1
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Life
Resistance Training Before Hyperalgesia Induction Promotes Analgesic Effects Through Central and Peripheral Biomarker Modulation in an Experimental Fibromyalgia-like Model
日期：2025-05-24
IF：3
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IBRO Neuroscience Reports
Electroacupuncture Enhances Nerve Regeneration and Functional Recovery in a Rat Model of Median Nerve Transection
日期：2025-11-01
IF：2.9
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NEUROSCIENCE
Short-Chain Fatty Acids on Cognitive Behaviours and Associated Neurochemistry Changes in Lps-Challenged Rats
日期：2025-04-04
IF：2.9
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Immunopharmacology and Immunotoxicology
Vildagliptin attenuates doxorubicin-induced hepatotoxicity via activating Nrf2/HO-1 and SIRT1 and suppressing NF-κB signals in rats
日期：2025-03-27
IF：2.9
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Immunopharmacology and Immunotoxicology
Reno-protective impact of diosmin and perindopril in amikacin-induced nephrotoxicity rat model: modulation of SIRT1/p53/C-FOS, NF-κB-p65, and keap-1/Nrf2/HO-1 signaling pathways
日期：2025-02-27
IF：2.9
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Immunopharmacology and Immunotoxicology
Punicalagin ameliorates lipopolysaccharide-induced inflammatory response in dental pulp cells via inhibition of the NF-κB/Wnt5a-ROR2 pathway
日期：2025-02-24
IF：2.9
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IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
Combined Bisoprolol and Trimetazidine ameliorate Arsenic trioxide -Induced Acute Myocardial Injury in Rats: Targeting PI3K/GSK-3β/Nrf2/HO-1 and NF-κB/iNOS Signaling Pathways, Inflammatory Mediators and Apoptosis
日期：2024-11-24
IF：2.9
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Immunopharmacology and Immunotoxicology
Reno-protective effect of fenofibrate and febuxostat against vancomycin-induced acute renal injury in rats: Targeting PPARγ/NF-κB/COX-II and AMPK/Nrf2/HO-1 signaling pathways
日期：2024-07-09
IF：2.9
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CELL BIOCHEMISTRY AND FUNCTION
Unveiling the Protective Potential of Crocin in Septic Acute Liver Injury via Assessment of TLR4/HGM1/NF-κB Signaling Pathway, Oxidative Stress and Heat Shock Response
日期：2025-02-17
IF：2.8
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European Journal of Medical Research
A2AR regulate inflammation through PKA/NF-κB signaling pathways in intervertebral disc degeneration
日期：2024-08-27
IF：2.8
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Evidence-Based Complementary and Alternative Medicine
Hydroxysafflor Yellow A (HSYA) Protects Endplate Chondrocytes Against IL-1β-Induced Injury Through Promoting Autophagy
日期：2022-07-04
IF：2.65
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BMC Gastroenterology
Melatonin alleviates diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome by modulating of the TLR4/MyD88/NF-κB pathway
日期：2025-07-28
IF：2.6
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Journal of the World Federation of Orthodontists
Biochemical and histopathological evaluation of rapid maxillary expansion in experimentally induced sinusitis: A controlled animal study
日期：2025-05-22
IF：2.6
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3 Biotech
Sodium propionate ameliorates lipopolysaccharide-induced acute respiratory distress syndrome in rats via the PI3K/AKT/mTOR signaling pathway
日期：2024-10-30
IF：2.6
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TISSUE & CELL
Gentisic acid ameliorates cisplatin-induced reprotoxicity through suppressing endoplasmic reticulum stress and upregulating Nrf2 pathway
日期：2023-10-23
IF：2.6
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Transl Androl Urol
Lycopene alleviates lipopolysaccharide-induced testicular injury in rats by activating the PPAR signaling pathway to integrate lipid metabolism and the inflammatory response
日期：2023-02-28
IF：2.479
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STEROIDS
Unraveling the impact of semaglutide in a diabetic rat model of testicular dysfunction: Insights into spermatogenesis pathways and miRNA-148a-5p
日期：2024-11-11
IF：2.1
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Open Medicine
Calycosin protects against chronic prostatitis in rats via inhibition of the p38MAPK/NF-κB pathway
日期：2023-07-11
IF：2.1
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International Urology and Nephrology
Alpha-pinene neutralizes cisplatin-induced reproductive toxicity in male rats through activation of Nrf2 pathway
日期：2023-09-20
IF：2
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ASSAY and Drug Development Technologies
Antidiabetic Evaluation of Kigelia pinnata Root Bark Extract in Streptozotocin-Induced Type-2 Diabetes Model of Rats
日期：2024-03-28
IF：1.8
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Open Medicine
Dioscin protects against chronic prostatitis through the TLR4/NF-κB pathway
日期：2024-08-20
IF：1.7
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Toxicology and Environmental Health Sciences
Anti-inflammatory and antioxidative effects of dexpanthenol on nicotine-induced lung injury in rats
日期：2023-08-04
IF：1.7
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Biochemical Genetics
Neuroprotective Role of THBS2 in Experimental Spinal Cord Injury Via its Anti-neuroinflammatory and Anti-apoptotic Properties
日期：2025-06-26
IF：1.6
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FOLIA MORPHOLOGICA
IGF 1, BDNF, and NGF mediate the neuro-modulatory role of stem cells in acrylamide-induced hippocampal toxic changes in rats
日期：2024-09-17
IF：1.2
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Ulusal Travma ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
Effects of pioglitazone and metformin on abdominal adhesion formation in an experimental model
日期：2024-06-05
IF：0.8
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Nigerian Journal of Clinical Practice
Effect of the Combination of Exercise and Metformin on Osteocalcin, Insülin, Interleukin-6, Glucose Levels, and Body Weights in Rats
日期：2024-06-15
IF：0.7
标准曲线
| Concentration (pg/mL) | OD | Corrected OD |
|---|---|---|
| 500.00 | 2.153 | 2.068 |
| 250.00 | 1.628 | 1.543 |
| 125.00 | 1.243 | 1.158 |
| 62.50 | 0.948 | 0.863 |
| 31.25 | 0.507 | 0.422 |
| 15.63 | 0.357 | 0.272 |
| 7.82 | 0.215 | 0.130 |
| 0.00 | 0.085 | 0.000 |
细密度
板内细密度（测定内的细密度）：CV%<8%
三个已知浓度的样品划分在1个酶标板上测试20次，，，以评估剖析板内细密度。。。
板间细密度（测定板间间细密度）：CV%<10%
三个已知浓度的样品划分在3个差别的酶标板上测试40次，，，以评估剖析板间的细密度。。。
接纳率
划分往差别样本中添加已知浓度的大鼠 IL6，，，
做接纳率实验，，，得出接纳率规模清静均接纳率
| 样本类型 | 接纳率规模 | 平均接纳率 |
|---|---|---|
| 血清(n=5) | 81-95% | 88% |
| EDTA 血浆(n=5) | 87-99% | 93% |
| Heparin 血浆(n=5) | 87-99% | 93% |
线性
将添加有大鼠 IL6的样天职别稀释2倍，，，4倍，，，8倍，，，16倍做接纳实验，，，得出接纳率规模
| 样本类型 | 1:2 | 1:4 | 1:8 | 1:16 |
|---|---|---|---|---|
| 血清(n=5) | 89-97% | 85-94% | 79-96% | 85-99% |
| EDTA 血浆(n=5) | 86-98% | 91-103% | 85-97% | 87-96% |
| Heparin 血浆(n=5) | 87-95% | 85-97% | 89-101% | 85-97% |
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